Researchers advanced integration frameworks and modeling methods to manage heterogeneity across components, domains, and interactions, pushing event-driven semantics and unified cyber-physical representations. Security, resilience, and dependable operation in critical infrastructures became central, with emphasis on attack detection and assurance. Healthcare cyber-physical systems, Internet of Things oriented designs leveraging Web-of-Things, and energy-focused CPS for smart grids and buildings broadened application horizons, promoting cross-domain interoperability and scalable architectures. Influential Works: A foundational line of work formalized heterogeneous, concurrent, and timed behavior in cyber-physical systems, using a vehicle management system to illustrate hybrid-system modeling and to seed formalism, verification, and tool support. Security-oriented analyses of the electric power grid highlighted cyber vulnerabilities and argued for risk-aware CPS design to ensure resilience of critical infrastructure. Architecture for Industry 4.0-based manufacturing demonstrated integrated CPS with real-time data fusion and cross-layer decision making, while surveys traced roots and identified key R&D challenges for future practice.